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Search Results for " stimulator of interferon genes "

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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T9029	STING-IN-3 C-171	STING	Immunology/Inflammation
	STING-IN-3 (C-171) 是干扰素基因刺激物 (STING) 的抑制剂。它与 STING 结合，抑制其棕榈酰化，并阻止 TBK1 的募集和磷酸化。
T13613	ChX710	STING	Immunology/Inflammation
	ChX710可以引发 I 型干扰素对细胞溶质 DNA 的反应，其特异性细胞干扰素刺激基因 (ISG) 诱导 ISRE 启动子序列和干扰素调节因子 (IRF) 3 的磷酸化。
T7329	C-178	STING	Immunology/Inflammation
	C-178 是 STING 选择性共价抑制剂，与 Cys91 结合抑制小鼠中由不同的激活剂引起的 STING 反应。
T13015	STING agonist-4	STING	Immunology/Inflammation
	STING agonist-4 是是干扰素基因 (STING) 受体刺激剂的激动剂，IC50为 20 nM。
T8798	MSA-2	STING	Immunology/Inflammation
	MSA-2 是可口服的非核苷酸 STING 激动剂，以具有纳摩尔亲和力的非共价二聚体形式与 STING 结合。它在同基因小鼠肿瘤模型中显示抗肿瘤活性，与抗 PD-1 协同作用，可刺激肿瘤分泌干扰素-β，诱导肿瘤消退，具有持久的抗肿瘤免疫。
T5674	H-151	STING	Immunology/Inflammation
	H-151 是一种 STING 拮抗剂，具有高效性和选择性。H-151 与 STING 的 Cys91 共价结合，抑制 Cys91 的棕榈酰化，从而抑制 STING 的活性。H-151 可用于体内外自身炎症性疾病的研究。
T9554	SN-008	STING	Immunology/Inflammation
	SN-008 是 SN-011 的低活性类似物，可作为阴性对照。
T9853	STING activator Compound 53	STING	Immunology/Inflammation
	基于 oxindole 核心结构的 STING activator Compound 53 在永生化细胞和原代细胞中表现出强大的 STING（人 EC50 185 nM）的靶向功能激活以及与 STING 激活一致的细胞因子诱导指纹。
T6919	Omaveloxolone RTA-408	Apoptosis; Others; Nrf2; STING	Apoptosis; Immunology/Inflammation; Others
	Omaveloxolone (RTA-408) 是一种抗氧化炎症调节剂，可激活Nrf2并抑制一氧化氮。它通过抑制 STING 依赖的 NF-κb 信号通路，来抑制破骨细胞的生成。
T5516	diABZI STING agonist-1 trihydrochloride	STING	Immunology/Inflammation
	diABZI STING agonist-1 trihydrochloride 是选择性的干扰素基因刺激受体(STING)激动剂，在人和小鼠中的 EC50值分别为 130 和 186 nM。
T5154	C-176 C176,STING inhibitor 1	STING	Immunology/Inflammation
	C-176 (STING inhibitor 1) 是干扰素基因刺激受体的一种强效共价抑制剂。
T8655	SR-717	STING	Immunology/Inflammation
	SR-717 是一种 cGAMP 的类似物，一种非核苷类 STING 激动剂，可以诱导 STING 形成“封闭”的激活构象。SR-717 具有抗肿瘤活性，可以促进免疫细胞的激活以及抗原的交叉提呈。
T9028	STING-IN-2 C-170	STING	Immunology/Inflammation
	STING-IN-2 (C-170) 是一种 STING 共价抑制剂，可抑制小鼠 STING (mmSTING) 和人类 STING (hsSTING)，可用于自身炎症性疾病的研究。
T8328	STING agonist-1 G10	Virus Protease; STING	Immunology/Inflammation; Microbiology/Virology
	STING agonist-1 (G10)是一种人类特异性 STING 激动剂，可引发针对新兴甲病毒的抗病毒活性。它抑制甲病毒属 VEEV 复制，IC90值为 24.57 μM。
T7081	CCCP Carbonyl Cyanide m-Chlorophenylhydrazone,Carbonyl cyanide 3-chlorophenylhydrazone,羰基氰化氯苯腙	Apoptosis; IκB/IKK; COX; Mitochondrial Metabolism; STING; IFNAR; Antibacterial	Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience; NF-κB
	CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) 是一种氧化磷酸化 (OXPHOS) 抑制剂，线粒体质子载体解偶联剂。CCCP 抑制 STING 及其下游信号分子 TBK1 和 IRF3 的激活。
T83775	STING Agonist 12L Stimulator of Interferon Genes Agonist 12L
	STING激动剂12L是一种刺激干扰素基因(STING)的激动剂。它与野生型STING结合(IC50 = 1.15 µM)，以及STING的R232、AQ和Q变体(IC50分别为1.06、0.61和1.12 µM)，并在THP-1和RAW 264.7细胞中诱导报告基因表达(EC50分别为0.38和12.94 µM)。STING激动剂12L (5 µM)在THP-1细胞中诱导IFNB1、CXCL10和IL6 mRNA的表达。在体内，STING激动剂12L (10 mg/kg)提高了血浆IFN-β水平，并且在B16/F10小鼠黑色素瘤模型中减少了肿瘤体积和肺转移灶的数量。
T83841	STING Agonist D61 D61,Stimulator of Interferon Genes Agonist D61
	STING激动剂D61（D61）是干扰素基因刺激剂(STING)的激动剂。它在基于细胞的分析中诱导IFN3诱导的分泌性碱性磷酸酶(SEAP)报告基因和IFN-β诱导的报告基因的表达（EC50分别为52.9和116 nM）。D61（4, 6, 和8 µM）增加了编码IFN-β和化学因子（C-X-C基序）配体10（CXCL10）的mRNA的表达以及TANK结合激酶1（TBK1）、IRF3和STING在THP-1单核细胞中的磷酸化。在体内，D61（每隔一天0.25 mg/kg）在CT26小鼠结肠癌模型中减少肿瘤体积，而不影响体重。
T6273	Vadimezan DMXAA,伐地美生,5,6-Dimethylxanthenone-4-acetic Acid,NSC 640488,ASA-404	Influenza Virus; VDA; STING; IFNAR	Angiogenesis; Immunology/Inflammation; Microbiology/Virology
	Vadimezan (DMXAA) 是一种血管破坏剂，一种鼠 STING 激动剂，也是一种细胞因子如 I 型 IFN 的诱导剂。Vadimezan 具有抗肿瘤活性，可以诱导肿瘤中的血流快速停止，但不影响正常组织中的血流。
T10252L2	ADU-S100 ammonium salt ML RR-S2 CDA ammonium salt,MIW815 ammonium salt	STING	Immunology/Inflammation
	ADU-S100 ammonium salt (ML RR-S2 CDA ammonium salt) 是干扰素基因刺激物的激活剂。 ADU-S100 ammonium salt 可导致有效的全身性肿瘤消退和免疫。
T9137	SN-011 [1,1'-Biphenyl]-4-carboxamide, N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl]-,GUN35901	STING	Immunology/Inflammation
	SN-011 (GUN35901) 是选择性 STING 抑制剂，可与环状二核苷酸 (CDN) 竞争 STING 二聚体的结合口袋，从而阻断 CDN 结合和 STING 激活。它用于 STING 驱动的自身免疫和炎症性疾病的研究，抑制 STING 信号传导的 IC50值为 76 nM。
T11035	diABZI STING agonist-1 (Tautomerism) diABZI STING agonist (Compound 3)	STING	Immunology/Inflammation
	diABZI STING agonist-1 (Tautomerism) (diABZI STING agonist (Compound 3)) 是一个选择性的干扰素基因刺激受体 (STING) 的激动剂，其在人和小鼠中的 EC50 值分别为 130 nM 和 186 nM。。
T72482	Dazostinag disodium	STING	Immunology/Inflammation
	Dazostinag disodium (TAK-676) 是一种新型干扰素基因刺激剂（STING）激动剂，也是一种免疫系统调节剂，具有抗肿瘤活性，可激活树突状细胞、自然杀伤细胞和 T 细胞。
T10252L3	ADU-S100 ML RR-S2 CDA,MIW815	Others	Others
	ADU-S100 is an activator of stimulator of interferon genes (STING).
T10834	CL656 c-[2’FdAMP(S)-2’FdIMP(S)]	Others	Others
	CL656 is a stimulator of interferon genes (STING) activator.
T10252	ADU-S100 disodium salt ML RR-S2 CDA disodium salt,MIW815 disodium salt	Others	Others
	ADU-S100 (MIW815) disodium salt is an activator of stimulator of interferon genes (STING).
T10252L	ADU-S100 enantiomer ammonium salt MIW815 enantiomer ammonium salt,ML RR-S2 CDA enantiomer ammonium salt	Others	Others
	ADU-S100 (MIW815) enantiomer ammonium salt is the less active enantiomer of ADU-S100. ADU-S100 is an activator of the stimulator of interferon genes (STING).
T38162	STING18
	STING18 is a competitive ligand of stimulator of interferon genes (STING; IC50 = 0.068 μM in a radioligand binding assay).1 It inhibits cGAMP-induced IFN-β production (IC50 = 11 μM) but does not stimulate IFN-β production (EC50 = >30 μM) in THP-1 cells. \|1. Siu, T., Altman, M.D., Baltus, G.A., et al. Discovery of a novel cGAMP competitive ligand of the inactive form of STING. Med. Chem. Lett. 10(1), 92-97 (2019).
T81082	STING-IN-7	STING	Immunology/Inflammation
	STING-IN-7（化合物 21），作为一种STING抑制剂，具有11.5 nM的IC50值，能够抑制STING与干扰素调节因子 3 (IRF3) 的磷酸化。
T38159	STING Agonist 12b
	STING agonist 12b is an agonist of stimulator of interferon genes (STING).1It binds to STING (Kd= 26.4 μM) and induces interferon reporter gene expression in cells expressing human or mouse STING (EC50s = 7.45 and 10.23 μM, respectively). STING agonist 12b (40 μM) induces expression of TNF-a, IL-6, IP-10, and IL-1b in THP-1 cells. 1.Hou, S., Lan, X.-j., Li, W., et al.Design, synthesis and biological evaluation of acridone analogues as novel STING receptor agonistsBioorg. Chem.95103556(2020)
T73746	diABZI STING agonist-1
	diABZISTINGagonist-1是一种针对干扰素基因刺激受体（STING）的选择性激动剂，其在人类和小鼠中的EC50值分别是130 nM和186 nM。
T38122	5'-pGpG (sodium salt)
	5'-pGpG is a linearized form of cyclic di-GMP, a bacterial second messenger that activates the host innate immune system through stimulator of interferon genes (STING).1,2,3It is a metabolite of cyclic di-GMP formedviahydrolysis by various phosphodiesterases (PDEs) that binds to the cyclic di-GMP-I riboswitch with reduced affinity compared to cyclic di-GMP.4,55'-pGpG is intended for use as a negative control for cyclic di-GMP signaling.
T82043	Iso5-2DC18
	Iso5-2DC18是用于合成含胺脂质的化合物。该脂质适用于mRNA传递、激活STING通路及表达抗肿瘤免疫效应。
T74726	CL845
	CL845 是 STING 激动剂 CL656 的类似物。CL845 可用于合成靶向 STING（干扰素基因刺激物）的可结合 PRR 配体。CL845 可用于癌症、免疫系统疾病或感染的研究。
T79320	Antitumor agent-114	STING	Immunology/Inflammation
	Antitumor agent-114为一种强效STING激动剂，具有激活免疫功能并在乳腺癌小鼠模型中缩减肿瘤体积的作用，适用于免疫与癌症疾病研究之用。
T75086	Dazostinag
	Dazostinag (TAK-676 free base) 为干扰素基因刺激剂 (STING) 蛋白的激动剂，展现出抗肿瘤活性。它能作为有效载荷 (payload) 用于合成抗体偶联活性分子 (ADC) 的构建。
T74676	STING agonist-20-Ala-amide-PEG2-C2-NH2
	STINGagonist-20-Ala-amide-PEG2-C2-NH2 是一种具有 STING (干扰素基因) 刺激能力的化合物，用于合成免疫刺激抗体偶联物 (ISAC) 并用于癌症研究。
T74268	STING agonist-13
	STINGagonist-13 是一种STING 激动剂，通过STING 介导的免疫激活进行癌症免疫。STINGagonist-13 可刺激STING 下游信号传导并促进 I 型干扰素免疫反应。STINGagonist-13 能显著降低肿瘤体积并具有免疫记忆衍生的癌症抑制活性。
T74677	STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA
	STINGagonist-20-Ala-amide-PEG2-C2-NH2 (Compound 30b) TFA，一种含干扰素基因（STING）刺激物的化学合成物，适用于免疫刺激抗体偶联物（ISAC）的合成，广泛应用于癌症研究领域。
T75011	STING-IN-5	STING	Immunology/Inflammation
	STING-IN-5为有效STING抑制剂，IC50达1.15 μM，能在巨噬细胞内抑制LSP诱导之NO合成，从而抑制炎症反应，主用于抗炎疾病与败血症研究。
T72516	IACS-8779 disodium
	IACS-8779 disodium 是一种高效的干扰素基因刺激蛋白 (STING) 激动剂，具有强大的全身性抗肿瘤功效。IACS-8779 disodium 在 B16 小鼠黑色素瘤模型中对STING 通路具有强烈活性，且具有卓越的抗肿瘤作用。
T35654	2'2'-cGAMP (sodium salt)
	2'2'-cGAMP is a synthetic dinucleotide (CDN) that contains non-canonical 2'5'-phosphodiester bonds. It binds to the adapter protein stimulator of interferon genes , which is a component of the innate immune response that activates the type I interferon pathway when bound to cyclic dinucleotides. 2'2-cGAMP shows weaker binding to STING than 2'3'-cGAMP but binds more strongly than 3'3'-cGAMP , cyclic di-GMP , or 3'2'-cGAMP, which bind in the micromolar range (Kds = 1.04, 1.21, or 1.61 μM, respecti...
T38091	3'3'-cGAMP (sodium salt)
	3'3'-cGAMP is a second messenger produced in bacteria by specific dinucleotide cyclases. It contains canonical 3'5'-phosphodiester bonds and regulates chemotaxis, colonization, and other cellular functions. 3'3'-cGAMP shows weaker binding to the adapter protein stimulator of interferon genes (STING; Kd = 1.04 μM) than 2'2'-cGAMP and 2'3'-cGAMP but has similar binding affinity to 3'2'-cGAMP (Kd = 1.61 μM) and cyclic di-GMP . 3'3'-cGAMP induces IFN-β mRNA expression in L929 cells (EC50 = 40.5 nM).
T79313	BI 7446	STING	Immunology/Inflammation
	BI 7446 是一种基于环状二核苷酸 (CDN) 的高效、特异性STING (干扰素基因刺激蛋白) 激动剂。它能激活所有五种STING变体并在体外诱导肿瘤特异性的免疫介导反应，从而消除肿瘤。此化合物适用于免疫肿瘤学领域的研究。
T38160	STING Agonist 1a
	STING agonist 1a is an agonist of stimulator of interferon genes (STING).1It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC50= 16.77 μM). STING agonist 1a (12.5-100 μM) induces expression of IFN-β, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells, an effect that can be reversed by STING knockout or the STING inhibitor H-151 . 1.Hou, H., Yang, R., Liu, X., et al.Discovery of triazoloquinoxaline as novel STING agonists via structure-based vir...
T35422	5'-pApA (sodium salt)
	5'-pApA is a linearized form of cyclic di-AMP, a bacterial second messenger that activates the host innate immune system through stimulator of interferon genes (STING).1,2,3,4It is a metabolite of cyclic di-AMP formedviahydrolysis by various phosphodiesterases (PDEs).55'-pApA is intended for use as a negative control for cyclic di-AMP signaling. 1.Burdette, D.L., Monroe, K.M., Sotelo-Troha, K., et al.STING is a direct innate immune sensor of cyclic-di-GMPNature478(7370)515-518(2011) 2.Parvatiyar...
T36461	CAY10748 CAY10748
	CAY10748 is an agonist of stimulator of interferon genes (STING; IC50= 0.3794 μM in a competition binding assay).1It activates STING in STING-expressing, but not STING knockout, THP-1 cells (EC50s = 0.287 and >100 μM, respectively, in a reporter assay). It induces phosphorylation of STING at the serine in position 366, as well as phosphorylation of TBK1 and IFN regulatory factor 3 (IRF3), indicating activation of the STING-TBK1-IRF3 signaling pathway. CAY10748 increases the secretion of IFN-β an...
T74693	CDN-A
	CDN-A为一种环二核苷酸，主要用于抗体-活性分子偶联物(ADC)的合成。作为先天免疫及适应性免疫反应的关键激活剂，环状二核苷酸能由内源性外来DNA或侵入性细菌病原体生成，在人体内通过促进干扰素基因表达激活先天免疫系统。
T83901	BDW568
	BDW568是一种刺激素干扰素基因（STING）的激动剂，同时是BDW-OH的前药形式。在使用THP-1细胞的报告基因测定中，它能诱导STING转录活性（EC50 = 7.6 µM）。BDW568（50 µM）在THP-1细胞中诱导TANK结合激酶1（TBK1）和IFN调节因子3（IRF3）的磷酸化。
T38161	STING Agonist C11 STING Agonist C11
	STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.1 It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 μM. STING agonist C11 induces phosphorylation of IFN regulatory factor 3 (IRF3) and increases expression of IFIT1 and viperin, but not IL-1β, IL-6, or IL-8 in THF cells in a STING-dependent manner. It reduces viral titers of chikungunya, Venezuelan equine encephalitis, o'nyong-nyong, Mayaro, and Ross River viruses gro...
T83874	S-72
	S-72是一种微管聚合抑制剂，以1, 3, 10 µM的浓度在无细胞测定中抑制微管聚合，并在MCF-7和耐紫杉醇的MCF-7/T乳腺癌细胞中降低细胞活性（IC50分别为15.64和26.32 nM）。50 nM浓度的S-72能抑制MCF-7和MCF-7/T细胞的迁移和侵袭，并减少划痕实验中的伤口闭合百分比。100 nM的S-72在MCF-7/T细胞中诱导G2/M期的细胞周期阻滞以及凋亡，并在同一浓度下抑制这些细胞中干扰素基因激活剂（STING）的激活。以每天15 mg/kg的剂量，S-72抑制了耐紫杉醇的MCF-7/T和MX-1/T小鼠异种移植模型中的肿瘤生长。

化合物

Cat.No: T9029

Synonym: C-171

Target: STING

Cat.No: T13613

Target: STING

Cat.No: T7329

Target: STING

STING agonist-4

Cat.No: T13015

Target: STING

Cat.No: T8798

Target: STING

Cat.No: T5674

Target: STING

Cat.No: T9554

Target: STING

STING activator Compound 53

Cat.No: T9853

Target: STING

Cat.No: T6919

Synonym: RTA-408

Target: Apoptosis, Others, Nrf2, STING

diABZI STING agonist-1 trihydrochloride

Cat.No: T5516

Target: STING

Cat.No: T5154

Synonym: C176,STING inhibitor 1

Target: STING

Cat.No: T8655

Target: STING

Cat.No: T9028

Synonym: C-170

Target: STING

STING agonist-1

Cat.No: T8328

Synonym: G10

Target: Virus Protease, STING

Cat.No: T7081

Synonym: Carbonyl Cyanide m-Chlorophenylhydrazone,Carbonyl cyanide 3-chlorophenylhydrazone,羰基氰化氯苯腙

Target: Apoptosis, IκB/IKK, COX, Mitochondrial Metabolism, STING, IFNAR, Antibacterial

STING Agonist 12L

Cat.No: T83775

Synonym: Stimulator of Interferon Genes Agonist 12L

STING Agonist D61

Cat.No: T83841

Synonym: D61,Stimulator of Interferon Genes Agonist D61

Cat.No: T6273

Synonym: DMXAA,伐地美生,5,6-Dimethylxanthenone-4-acetic Acid,NSC 640488,ASA-404

Target: Influenza Virus, VDA, STING, IFNAR

ADU-S100 ammonium salt

Cat.No: T10252L2

Synonym: ML RR-S2 CDA ammonium salt,MIW815 ammonium salt

Target: STING

Cat.No: T9137

Synonym: [1,1'-Biphenyl]-4-carboxamide, N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl]-,GUN35901

Target: STING

diABZI STING agonist-1 (Tautomerism)

Cat.No: T11035

Synonym: diABZI STING agonist (Compound 3)

Target: STING

Dazostinag disodium

Cat.No: T72482

Target: STING

Cat.No: T10252L3

Synonym: ML RR-S2 CDA,MIW815

Target: Others

Cat.No: T10834

Synonym: c-[2’FdAMP(S)-2’FdIMP(S)]

Target: Others

ADU-S100 disodium salt

Cat.No: T10252

Synonym: ML RR-S2 CDA disodium salt,MIW815 disodium salt

Target: Others

ADU-S100 enantiomer ammonium salt

Cat.No: T10252L

Synonym: MIW815 enantiomer ammonium salt,ML RR-S2 CDA enantiomer ammonium salt

Target: Others

Cat.No: T38162

Cat.No: T81082

Target: STING

STING Agonist 12b

Cat.No: T38159

diABZI STING agonist-1

Cat.No: T73746

5'-pGpG (sodium salt)

Cat.No: T38122

Cat.No: T82043

Cat.No: T74726

Antitumor agent-114

Cat.No: T79320

Target: STING

Cat.No: T75086

STING agonist-20-Ala-amide-PEG2-C2-NH2

Cat.No: T74676

STING agonist-13

Cat.No: T74268

STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA

Cat.No: T74677

Cat.No: T75011

Target: STING

IACS-8779 disodium

Cat.No: T72516

2'2'-cGAMP (sodium salt)

Cat.No: T35654

3'3'-cGAMP (sodium salt)

Cat.No: T38091

Cat.No: T79313

Target: STING

STING Agonist 1a

Cat.No: T38160

5'-pApA (sodium salt)

Cat.No: T35422

Cat.No: T36461

Synonym: CAY10748

Cat.No: T74693

Cat.No: T83901

STING Agonist C11

Cat.No: T38161

Synonym: STING Agonist C11

Cat.No: T83874

Cat. No.	Product Name	Target	Signaling Pathways
T73717	cGAMP diammonium
	cGAMP (Cyclic GMP-AMPP) diammonium 是一种内源性第二信使，通过触发干扰素的产生来响应胞浆 DNA。它通过激活干扰素基因刺激因子（STING），启动信号级联，进而导致I型干扰素及其他免疫介质的生成。

天然产物

cGAMP diammonium

Cat.No: T73717

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